In-vivo integration of soft neural probes through high-resolution printing of liquid electronics on the cranium
Young-Geun Park, Yong Won Kwon, Chin Su Koh, Enji Kim, Dong Ha Lee, Sumin Kim, Jongmin Mun, Yeon-Mi Hong, Sanghoon Lee, Ju-Young Kim, Jae-Hyun Lee, Hyun Ho Jung, Jinwoo Cheon, Jin Woo Chang, and Jang-Ung Park
Nature Communications, Feb 2024
Conventional neural probes are rigid, causing damages when implanted in freely moving animals. To address this issue, we present a soft, conformable neural interface system designed for long-term, stable monitoring of single-unit neural activity in freely moving subjects. This system integrates soft neural probes implanted in the brain with liquid metal-based electronics printed on the cranial surface. In-vivo mouse studies, employing dimensionality reduction, clustering analysis, and goodness-of-fit testing, provide statistical evidence of stable neural recordings over 33 weeks and behavior-induced activation across multiple brain regions during T-maze tests.